Design and Solidification of Fast-Releasing Clofazimine Nanoparticles for Treatment of Cryptosporidiosis

[Image: see text] Clofazimine, a lipophilic (log P = 7.66) riminophenazine antibiotic approved by the US Food and Drug Administration (FDA) with a good safety record, was recently identified as a lead hit for cryptosporidiosis through a high-throughput phenotypic screen. Cryptosporidiosis requires f...

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Bibliographische Detailangaben
Veröffentlicht in:Mol Pharm
Hauptverfasser: Zhang, Yingyue, Feng, Jie, McManus, Simon A., Lu, Hoang D., Ristroph, Kurt D., Cho, Eugene J., Dobrijevic, Ellen L., Chan, Hak-Kim, Prud’homme, Robert K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2017
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5627342/
https://ncbi.nlm.nih.gov/pubmed/28929769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.molpharmaceut.7b00521
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