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Mechanistic insights in X-chromosome inactivation
X-chromosome inactivation (XCI) is a critical epigenetic mechanism for balancing gene dosage between XY males and XX females in eutherian mammals. A long non-coding RNA (lncRNA), XIST, and its associated proteins orchestrate this multi-step process, resulting in the inheritable silencing of one of t...
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| Publicado no: | Philos Trans R Soc Lond B Biol Sci |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Royal Society
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5627158/ https://ncbi.nlm.nih.gov/pubmed/28947655 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rstb.2016.0356 |
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