Spen links RNA-mediated endogenous retrovirus silencing and X chromosome inactivation

The Xist lncRNA mediates X chromosome inactivation (XCI). Here we show that Spen, an Xist-binding repressor protein essential for XCI , binds to ancient retroviral RNA, performing a surveillance role to recruit chromatin silencing machinery to these parasitic loci. Spen loss activates a subset of en...

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Detalles Bibliográficos
Publicado en:eLife
Main Authors: Carter, Ava C, Xu, Jin, Nakamoto, Meagan Y, Wei, Yuning, Zarnegar, Brian J, Shi, Quanming, Broughton, James P, Ransom, Ryan C, Salhotra, Ankit, Nagaraja, Surya D, Li, Rui, Dou, Diana R, Yost, Kathryn E, Cho, Seung-Woo, Mistry, Anil, Longaker, Michael T, Khavari, Paul A, Batey, Robert T, Wuttke, Deborah S, Chang, Howard Y
Formato: Artigo
Idioma:Inglês
Publicado: eLife Sciences Publications, Ltd 2020
Assuntos:
Chromosomes and Gene Expression
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7282817/
https://ncbi.nlm.nih.gov/pubmed/32379046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.54508
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