Topoisomerase 1 Inhibition Promotes Cyclic GMP-AMP Synthase-Dependent Antiviral Responses

Inflammatory responses, while essential for pathogen clearance, can also be deleterious to the host. Chemical inhibition of topoisomerase 1 (Top1) by low-dose camptothecin (CPT) can suppress transcriptional induction of antiviral and inflammatory genes and protect animals from excessive and damaging...

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Bibliographic Details
Published in:mBio
Main Authors: Pépin, Geneviève, Nejad, Charlotte, Ferrand, Jonathan, Thomas, Belinda J., Stunden, H. James, Sanij, Elaine, Foo, Chwan-Hong, Stewart, Cameron R., Cain, Jason E., Bardin, Philip G., Williams, Bryan R. G., Gantier, Michael P.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2017
Subjects:
Observation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5626974/
https://ncbi.nlm.nih.gov/pubmed/28974621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.01611-17
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