TC299423, a Novel Agonist for Nicotinic Acetylcholine Receptors

(E)-5-(Pyrimidin-5-yl)-1,2,3,4,7,8-hexahydroazocine (TC299423) is a novel agonist for nicotinic acetylcholine receptors (nAChRs). We examined its efficacy, affinity, and potency for α6β2(∗) (α6β2-containing), α4β2(∗), and α3β4(∗) nAChRs, using [(125)I]-epibatidine binding, whole-cell patch-clamp rec...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Wall, Teagan R., Henderson, Brandon J., Voren, George, Wageman, Charles R., Deshpande, Purnima, Cohen, Bruce N., Grady, Sharon R., Marks, Michael J., Yohannes, Daniel, Kenny, Paul J., Bencherif, Merouane, Lester, Henry A.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5626944/
https://ncbi.nlm.nih.gov/pubmed/29033834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2017.00641
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