Structural differences determine the relative selectivity of nicotinic compounds for native α4β2*-, α6β2*-, α3β4*- and α7-nicotine acetylcholine receptors

Mammalian brain expresses multiple nicotinic acetylcholine receptor (nAChR) subtypes that differ in subunit composition, sites of expression and pharmacological and functional properties. Among known subtypes of receptors, α4β2* and α6β2*-nAChR have the highest affinity for nicotine (where * indicat...

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Main Authors: Grady, Sharon R., Drenan, Ryan M., Breining, Scott R., Yohannes, Daniel, Wageman, Charles R., Fedorov, Nikolai B., McKinney, Sheri, Whiteaker, Paul, Bencherif, Merouane, Lester, Henry A., Marks, Michael J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2849849/
https://ncbi.nlm.nih.gov/pubmed/20114055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2010.01.013
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