The antitumor effects of vaccine-activated CD8(+) T cells associate with weak TCR signaling and induction of stem-like memory T cells

To understand why vaccine-activated tumor-specific T cells often fail to generate antitumor effects, we studied two α-fetoprotein–specific CD8(+) T cells (Tet(499) and Tet(212)) that had different antitumor effects. We found that Tet(499) required high antigen doses for re-activation, but could surv...

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Detalhes bibliográficos
Publicado no:Cancer Immunol Res
Main Authors: Wu, Sha, Zhu, Wei, Peng, Yibing, Wang, Lan, Hong, Yuan, Huang, Lei, Dong, Dayong, Xie, Junping, Merchen, Todd, Kruse, Edward, Guo, Zong Sheng, Bartlett, David, Fu, Ning, He, Yukai
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5626646/
https://ncbi.nlm.nih.gov/pubmed/28851693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-17-0016
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