Stabilization of dynamic microtubules by mDia1 drives Tau-dependent Aβ(1–42) synaptotoxicity

Oligomeric Amyloid β(1–42) (Aβ) plays a crucial synaptotoxic role in Alzheimer’s disease, and hyperphosphorylated tau facilitates Aβ toxicity. The link between Aβ and tau, however, remains controversial. In this study, we find that in hippocampal neurons, Aβ acutely induces tubulin posttranslational...

Cijeli opis

Spremljeno u:
Bibliografski detalji
Izdano u:J Cell Biol
Glavni autori: Qu, Xiaoyi, Yuan, Feng Ning, Corona, Carlo, Pasini, Silvia, Pero, Maria Elena, Gundersen, Gregg G., Shelanski, Michael L., Bartolini, Francesca
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2017
Teme:
Research Articles
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5626542/
https://ncbi.nlm.nih.gov/pubmed/28877993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201701045
Oznake: Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!

Similar Items