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Stabilization of dynamic microtubules by mDia1 drives Tau-dependent Aβ(1–42) synaptotoxicity

Oligomeric Amyloid β(1–42) (Aβ) plays a crucial synaptotoxic role in Alzheimer’s disease, and hyperphosphorylated tau facilitates Aβ toxicity. The link between Aβ and tau, however, remains controversial. In this study, we find that in hippocampal neurons, Aβ acutely induces tubulin posttranslational...

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Bibliografski detalji
Izdano u:J Cell Biol
Glavni autori: Qu, Xiaoyi, Yuan, Feng Ning, Corona, Carlo, Pasini, Silvia, Pero, Maria Elena, Gundersen, Gregg G., Shelanski, Michael L., Bartolini, Francesca
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2017
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Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5626542/
https://ncbi.nlm.nih.gov/pubmed/28877993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201701045
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