Stabilization of dynamic microtubules by mDia1 drives Tau-dependent Aβ(1–42) synaptotoxicity

Oligomeric Amyloid β(1–42) (Aβ) plays a crucial synaptotoxic role in Alzheimer’s disease, and hyperphosphorylated tau facilitates Aβ toxicity. The link between Aβ and tau, however, remains controversial. In this study, we find that in hippocampal neurons, Aβ acutely induces tubulin posttranslational...

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Detalhes bibliográficos
Publicado no:J Cell Biol
Main Authors: Qu, Xiaoyi, Yuan, Feng Ning, Corona, Carlo, Pasini, Silvia, Pero, Maria Elena, Gundersen, Gregg G., Shelanski, Michael L., Bartolini, Francesca
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5626542/
https://ncbi.nlm.nih.gov/pubmed/28877993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201701045
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