Stabilization of dynamic microtubules by mDia1 drives Tau-dependent Aβ(1–42) synaptotoxicity

Oligomeric Amyloid β(1–42) (Aβ) plays a crucial synaptotoxic role in Alzheimer’s disease, and hyperphosphorylated tau facilitates Aβ toxicity. The link between Aβ and tau, however, remains controversial. In this study, we find that in hippocampal neurons, Aβ acutely induces tubulin posttranslational...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Cell Biol
Prif Awduron: Qu, Xiaoyi, Yuan, Feng Ning, Corona, Carlo, Pasini, Silvia, Pero, Maria Elena, Gundersen, Gregg G., Shelanski, Michael L., Bartolini, Francesca
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The Rockefeller University Press 2017
Pynciau:
Research Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5626542/
https://ncbi.nlm.nih.gov/pubmed/28877993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201701045
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