Cbfβ2 deficiency preserves Langerhans cell precursors by lack of selective TGFβ receptor signaling

The mouse Langerhans cell (LC) network is established through the differentiation of embryonic LC precursors. BMP7 and TGFβ1 initiate cellular signaling that is essential for inducing LC differentiation and preserving LCs in a quiescent state, respectively. Here we show that loss of Cbfβ2, one of tw...

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Publicat a:J Exp Med
Autors principals: Tenno, Mari, Shiroguchi, Katsuyuki, Muroi, Sawako, Kawakami, Eiryo, Koseki, Keita, Kryukov, Kirill, Imanishi, Tadashi, Ginhoux, Florent, Taniuchi, Ichiro
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2017
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5626404/
https://ncbi.nlm.nih.gov/pubmed/28814567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20170729
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