LRRK2 promotes the activation of NLRC4 inflammasome during Salmonella Typhimurium infection

Although genetic polymorphisms in the LRRK2 gene are associated with a variety of diseases, the physiological function of LRRK2 remains poorly understood. In this study, we report a crucial role for LRRK2 in the activation of the NLRC4 inflammasome during host defense against Salmonella enteric sero...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Liu, Weiwei, Liu, Xia’nan, Li, Yu, Zhao, Junjie, Liu, Zhenshan, Hu, Zhuqin, Wang, Ying, Yao, Yufeng, Miller, Aaron W., Su, Bing, Cookson, Mark R., Li, Xiaoxia, Kang, Zizhen
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5626397/
https://ncbi.nlm.nih.gov/pubmed/28821568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20170014
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