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Single rat muscle Na(+) channel mutation confers batrachotoxin autoresistance found in poison-dart frog Phyllobates terribilis

Poison-dart Phyllobates terribilis frogs sequester lethal amounts of steroidal alkaloid batrachotoxin (BTX) in their skin as a defense mechanism against predators. BTX targets voltage-gated Na(+) channels and enables them to open persistently. How BTX autoresistance arises in such frogs remains a my...

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Bibliografiska uppgifter
I publikationen:Proc Natl Acad Sci U S A
Huvudupphovsmän: Wang, Sho-Ya, Wang, Ging Kuo
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2017
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5625918/
https://ncbi.nlm.nih.gov/pubmed/28874544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1707873114
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