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Single rat muscle Na(+) channel mutation confers batrachotoxin autoresistance found in poison-dart frog Phyllobates terribilis
Poison-dart Phyllobates terribilis frogs sequester lethal amounts of steroidal alkaloid batrachotoxin (BTX) in their skin as a defense mechanism against predators. BTX targets voltage-gated Na(+) channels and enables them to open persistently. How BTX autoresistance arises in such frogs remains a my...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5625918/ https://ncbi.nlm.nih.gov/pubmed/28874544 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1707873114 |
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