Intestinal type 1 regulatory T cells migrate to periphery to suppress diabetogenic T cells and prevent diabetes development

Growing insight into the pathogenesis of autoimmune diseases and numerous studies in preclinical models highlights the potential of regulatory T cells to restore tolerance. By using non-obese diabetic (NOD) BDC2.5 TCR-transgenic (Tg), and IL-10 and Foxp3 double-reporter mice, we demonstrate that alt...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Yu, Hua, Gagliani, Nicola, Ishigame, Harumichi, Huber, Samuel, Zhu, Shu, Esplugues, Enric, Herold, Kevan C., Wen, Li, Flavell, Richard A.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2017
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5625908/
https://ncbi.nlm.nih.gov/pubmed/28894001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1705599114
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