Effective Encapsulation and Biological Activity of Phosphorylated Chemotherapeutics in Calcium Phosphosilicate Nanoparticles for the Treatment of Pancreatic Cancer

Drug resistant cancers like pancreatic ductal adenocarcinoma (PDAC) are difficult to treat, and nanoparticle drug delivery systems can overcome some of the limitations of conventional systemic chemotherapy. In this study, we demonstrate that FdUMP and dFdCMP, the bioactive, phosphorylated metabolite...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Nanomedicine
Egile Nagusiak: Loc, Welley S., Linton, Samuel S., Wilczynski, Zachary R., Matters, Gail L., McGovern, Christopher O., Abraham, Thomas, Fox, Todd, Gigliotti, Christopher M., Tang, Xiaomeng, Tabakovic, Amra, Martin, Jo Ann, Clawson, Gary A., Smith, Jill P., Butler, Peter J., Kester, Mark, Adair, James H.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2017
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5625839/
https://ncbi.nlm.nih.gov/pubmed/28673852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nano.2017.06.017
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