Effective Encapsulation and Biological Activity of Phosphorylated Chemotherapeutics in Calcium Phosphosilicate Nanoparticles for the Treatment of Pancreatic Cancer

Drug resistant cancers like pancreatic ductal adenocarcinoma (PDAC) are difficult to treat, and nanoparticle drug delivery systems can overcome some of the limitations of conventional systemic chemotherapy. In this study, we demonstrate that FdUMP and dFdCMP, the bioactive, phosphorylated metabolite...

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Detalhes bibliográficos
Publicado no:Nanomedicine
Main Authors: Loc, Welley S., Linton, Samuel S., Wilczynski, Zachary R., Matters, Gail L., McGovern, Christopher O., Abraham, Thomas, Fox, Todd, Gigliotti, Christopher M., Tang, Xiaomeng, Tabakovic, Amra, Martin, Jo Ann, Clawson, Gary A., Smith, Jill P., Butler, Peter J., Kester, Mark, Adair, James H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5625839/
https://ncbi.nlm.nih.gov/pubmed/28673852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nano.2017.06.017
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