Mitochondria-Targeted Antioxidants SkQ1 and MitoTEMPO Failed to Exert a Long-Term Beneficial Effect in Murine Polymicrobial Sepsis

Mitochondrial-derived reactive oxygen species have been deemed an important contributor in sepsis pathogenesis. We investigated whether two mitochondria-targeted antioxidants (mtAOX; SkQ1 and MitoTEMPO) improved long-term outcome, lessened inflammation, and improved organ homeostasis in polymicrobia...

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Bibliografiske detaljer
Udgivet i:Oxid Med Cell Longev
Main Authors: Rademann, Pia, Weidinger, Adelheid, Drechsler, Susanne, Meszaros, Andras, Zipperle, Johannes, Jafarmadar, Mohammad, Dumitrescu, Sergiu, Hacobian, Ara, Ungelenk, Luisa, Röstel, Franziska, Kaszaki, Jozsef, Szabo, Andrea, Skulachev, Vladimir P., Bauer, Michael, Bahrami, Soheyl, Weis, Sebastian, Kozlov, Andrey V., Osuchowski, Marcin F.
Format: Artigo
Sprog:Inglês
Udgivet: Hindawi 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5625755/
https://ncbi.nlm.nih.gov/pubmed/29104729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2017/6412682
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