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Coordinate Regulation of TET2 and EBNA2 Controls the DNA Methylation State of Latent Epstein-Barr Virus

Epstein-Barr virus (EBV) latency and its associated carcinogenesis are regulated by dynamic changes in DNA methylation of both virus and host genomes. We show here that the ten-eleven translocation 2 (TET2) gene, implicated in hydroxymethylation and active DNA demethylation, is a key regulator of EB...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Lu, Fang, Wiedmer, Andreas, Martin, Kayla A., Wickramasinghe, Priyankara J. M. S., Kossenkov, Andrew V., Lieberman, Paul M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5625499/
https://ncbi.nlm.nih.gov/pubmed/28794029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00804-17
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