Potential of High-Affinity, Slow Off-Rate Modified Aptamer Reagents for Mycobacterium tuberculosis Proteins as Tools for Infection Models and Diagnostic Applications

Direct pathogen detection in blood to diagnose active tuberculosis (TB) has been difficult due to low levels of circulating antigens or due to the lack of specific, high-affinity binding reagents and reliable assays with adequate sensitivity. We sought to determine whether slow off-rate modified apt...

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Veröffentlicht in:J Clin Microbiol
Hauptverfasser: Russell, Theresa M., Green, Louis S., Rice, Taylor, Kruh-Garcia, Nicole A., Dobos, Karen, De Groote, Mary A., Hraha, Thomas, Sterling, David G., Janjic, Nebojsa, Ochsner, Urs A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2017
Schlagworte:
Mycobacteriology and Aerobic Actinomycetes
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5625393/
https://ncbi.nlm.nih.gov/pubmed/28794178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JCM.00469-17
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