Potential of High-Affinity, Slow Off-Rate Modified Aptamer Reagents for Mycobacterium tuberculosis Proteins as Tools for Infection Models and Diagnostic Applications

Direct pathogen detection in blood to diagnose active tuberculosis (TB) has been difficult due to low levels of circulating antigens or due to the lack of specific, high-affinity binding reagents and reliable assays with adequate sensitivity. We sought to determine whether slow off-rate modified apt...

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Detaylı Bibliyografya
Yayımlandı:J Clin Microbiol
Asıl Yazarlar: Russell, Theresa M., Green, Louis S., Rice, Taylor, Kruh-Garcia, Nicole A., Dobos, Karen, De Groote, Mary A., Hraha, Thomas, Sterling, David G., Janjic, Nebojsa, Ochsner, Urs A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2017
Konular:
Mycobacteriology and Aerobic Actinomycetes
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5625393/
https://ncbi.nlm.nih.gov/pubmed/28794178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JCM.00469-17
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