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Nickel-catalyzed C–H/N–H annulation of aromatic amides with alkynes in the absence of a specific chelation system

The Ni-catalyzed reaction of aromatic amides with alkynes in the presence of KOBu(t) involves C–H/N–H oxidative annulation to give 1(2H)-isoquinolinones. A key to the success of the reaction is the use of a catalytic amount of strong base, such as KOBu(t). The reaction shows a high functional group...

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Bibliografiska uppgifter
I publikationen:Chem Sci
Huvudupphovsmän: Obata, Atsushi, Ano, Yusuke, Chatani, Naoto
Materialtyp: Artigo
Språk:Inglês
Publicerad: Royal Society of Chemistry 2017
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5625264/
https://ncbi.nlm.nih.gov/pubmed/28989692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7sc01750b
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