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Nickel-catalyzed C–O/N–H, C–S/N–H, and C–CN/N–H annulation of aromatic amides with alkynes: C–O, C–S, and C–CN activation

The Ni-catalyzed reaction of ortho-phenoxy-substituted aromatic amides with alkynes in the presence of LiO(t)Bu as a base results in C–O/N–H annulation with the formation of 1(2H)-isoquinolinones. The use of a base is essential for the reaction to proceed. The reaction proceeds, even in the absence...

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Bibliografiske detaljer
Udgivet i:Chem Sci
Main Authors: Iyori, Yasuaki, Ueno, Rina, Morishige, Aoi, Chatani, Naoto
Format: Artigo
Sprog:Inglês
Udgivet: The Royal Society of Chemistry 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8179272/
https://ncbi.nlm.nih.gov/pubmed/34163938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0sc06056a
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