Pharmacological hypothesis: Nitric oxide‐induced inhibition of ADAM‐17 activity as well as vesicle release can in turn prevent the production of soluble endothelin‐converting enzyme

Endothelin‐1 (ET‐1) and nitric oxide (NO) are two highly potent vasoactive molecules with opposing effects on the vasculature. Endothelin‐converting enzyme (ECE) and nitric oxide synthase (NOS) catalyse the production of ET‐1 and NO, respectively. It is well established that these molecules play a c...

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Detalhes bibliográficos
Publicado no:Pharmacol Res Perspect
Main Authors: Kuruppu, Sanjaya, Rajapakse, Niwanthi W., Parkington, Helena C., Smith, Ian
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Reviews
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5625149/
https://ncbi.nlm.nih.gov/pubmed/28971608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.335
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