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Synthesis of 3-O-sulfated oligosaccharides to understand the relationship between structures and functions of heparan sulfate

The sulfation at the 3-OH position of glucosamine is an important modification in forming structural domains for heparan sulfate to enable its biological functions. Seven 3-O-sulfotransferase isoforms in the human genome are involved in the biosynthesis of 3-O-sulfated heparan sulfate. As a rare mod...

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Publicado en:J Am Chem Soc
Autores principales: Wang, Zhangjie, Hsieh, Po-Hung, Xu, Yongmei, Thieker, David, Chai, Evangeline Juan En, Xie, Shaoshuai, Cooley, Brian, Woods, Robert J., Chi, Lianli, Liu, Jian
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5624809/
https://ncbi.nlm.nih.gov/pubmed/28340300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b01923
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