DEC2 Blocks the Effect of the ARNTL2/NPAS2 Dimer on the Expression of PER3 and DBP

The expression of clock genes ARNTL2, NPAS2 and DEC2 are disturbed in rheumatoid arthritis, an autoimmune disease with circadian variation of symptoms. We have shown that TNF is a potent inducer of these genes. We investigated the regulation of ARNTL2 and NPAS2 by TNF and elucidated their effect on...

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Bibliografiske detaljer
Udgivet i:J Circadian Rhythms
Main Authors: Olkkonen, Juri, Kouri, Vesa-Petteri, Kuusela, Elina, Ainola, Mari, Nordström, Dan, Eklund, Kari K., Mandelin, Jami
Format: Artigo
Sprog:Inglês
Udgivet: Ubiquity Press 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5624067/
https://ncbi.nlm.nih.gov/pubmed/30210560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5334/jcr.149
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