Circadian Timekeeping Is Disturbed in Rheumatoid Arthritis at Molecular Level

INTRODUCTION: Patients with rheumatoid arthritis (RA) have disturbances in the hypothalamic-pituitary-adrenal (HPA) axis. These are reflected in altered circadian rhythm of circulating serum cortisol, melatonin and IL-6 levels and in chronic fatigue. We hypothesized that the molecular machinery resp...

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Main Authors: Kouri, Vesa-Petteri, Olkkonen, Juri, Kaivosoja, Emilia, Ainola, Mari, Juhila, Juuso, Hovatta, Iiris, Konttinen, Yrjö T., Mandelin, Jami
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3546002/
https://ncbi.nlm.nih.gov/pubmed/23335987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0054049
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