An Alzheimer‐associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function

Sequence variations occurring in the gene encoding the triggering receptor expressed on myeloid cells 2 (TREM2) support an essential function of microglia and innate immunity in the pathogenesis of Alzheimer's disease (AD) and other neurodegenerative disorders. TREM2 matures within the secretor...

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Vydáno v:EMBO Mol Med
Hlavní autoři: Schlepckow, Kai, Kleinberger, Gernot, Fukumori, Akio, Feederle, Regina, Lichtenthaler, Stefan F, Steiner, Harald, Haass, Christian
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2017
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5623859/
https://ncbi.nlm.nih.gov/pubmed/28855300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201707672
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