An oral form of methylglyoxal-bis-guanylhydrazone reduces monocyte activation and traffic to the dorsal root ganglia in a primate model of HIV-peripheral neuropathy

Peripheral neuropathy (PN) is a major comorbidity of HIV infection that is caused in part by chronic immune activation. HIV-PN is associated with infiltration of monocytes/macrophages to the dorsal root ganglia (DRG) causing neuronal loss and formation of Nageotte nodules. Here, we used an oral form...

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Detalhes bibliográficos
Publicado no:J Neurovirol
Main Authors: Lakritz, Jessica R., Yalamanchili, Samshita, Polydefkis, Michael J., Miller, Andrew D., McGrath, Michael S., Williams, Kenneth C., Burdo, Tricia H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5623097/
https://ncbi.nlm.nih.gov/pubmed/28462488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13365-017-0529-9
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