Spontaneous Secretion of the Citrullination Enzyme PAD2 and Cell Surface Exposure of PAD4 by Neutrophils

Autoantibodies directed against citrullinated epitopes of proteins are highly diagnostic of rheumatoid arthritis (RA), and elevated levels of protein citrullination can be found in the joints of patients with RA. Calcium-dependent peptidyl-arginine deiminases (PAD) are the enzymes responsible for ci...

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Détails bibliographiques
Publié dans:Front Immunol
Auteurs principaux: Zhou, Yebin, Chen, Bo, Mittereder, Nanette, Chaerkady, Raghothama, Strain, Martin, An, Ling-Ling, Rahman, Saifur, Ma, Wenting, Low, Choon Pei, Chan, Denice, Neal, Frances, Bingham, Clifton O., Sampson, Kevon, Darrah, Erika, Siegel, Richard M., Hasni, Sarfaraz, Andrade, Felipe, Vousden, Katherine A., Mustelin, Tomas, Sims, Gary P.
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2017
Sujets:
Immunology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5622307/
https://ncbi.nlm.nih.gov/pubmed/28993780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.01200
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