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Perspective on Protein Arginine Deiminase Activity—Bicarbonate Is a pH-Independent Regulator of Citrullination
Protein citrullination catalyzed by peptidyl arginine deiminase (PADs) is involved in autoimmune disease pathogenesis, especially in rheumatoid arthritis. Calcium is a key regulator of PAD activity, but under normal physiological conditions it remains uncertain how intracellular calcium levels can b...
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Main Authors: | , , |
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Formato: | Artigo |
Idioma: | Inglês |
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Frontiers Media S.A.
2018-01-01
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Colecção: | Frontiers in Immunology |
Assuntos: | |
Acesso em linha: | http://journal.frontiersin.org/article/10.3389/fimmu.2018.00034/full |
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