Mdm2 regulates cardiac contractility by inhibiting GRK2-mediated desensitization of β-adrenergic receptor signaling

The oncoprotein Mdm2 is a RING domain–containing E3 ubiquitin ligase that ubiquitinates G protein–coupled receptor kinase 2 (GRK2) and β-arrestin2, thereby regulating β-adrenergic receptor (βAR) signaling and endocytosis. Previous studies showed that cardiac Mdm2 expression is critical for controlli...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Jean-Charles, Pierre-Yves, Yu, Samuel Mon-Wei, Abraham, Dennis, Kommaddi, Reddy Peera, Mao, Lan, Strachan, Ryan T., Zhang, Zhu-Shan, Bowles, Dawn E., Brian, Leigh, Stiber, Jonathan A., Jones, Stephen N., Koch, Walter J., Rockman, Howard A., Shenoy, Sudha K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5621915/
https://ncbi.nlm.nih.gov/pubmed/28878120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.95998
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