HDAC inhibition induces HIV-1 protein and enables immune-based clearance following latency reversal

Promising therapeutic approaches for eradicating HIV include transcriptional activation of provirus from latently infected cells using latency-reversing agents (LRAs) and immune-mediated clearance to purge reservoirs. Accurate detection of cells capable of producing viral antigens and virions, and t...

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Publicado en:JCI Insight
Main Authors: Wu, Guoxin, Swanson, Michael, Talla, Aarthi, Graham, Donald, Strizki, Julie, Gorman, Daniel, Barnard, Richard J.O., Blair, Wade, Søgaard, Ole S., Tolstrup, Martin, Østergaard, Lars, Rasmussen, Thomas A., Sekaly, Rafick-Pierre, Archin, Nancie M., Margolis, David M., Hazuda, Daria J., Howell, Bonnie J.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2017
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5621903/
https://ncbi.nlm.nih.gov/pubmed/28814661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.92901
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