VISTA.COMP — an engineered checkpoint receptor agonist that potently suppresses T cell–mediated immune responses

V-domain immunoglobulin suppressor of T cell activation (VISTA) is a recently discovered immune checkpoint ligand that functions to suppress T cell activity. The therapeutic potential of activating this immune checkpoint pathway to reduce inflammatory responses remains untapped, largely due to the i...

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Vydáno v:JCI Insight
Hlavní autoři: Prodeus, Aaron, Abdul-Wahid, Aws, Sparkes, Amanda, Fischer, Nicholas W., Cydzik, Marzena, Chiang, Nicholas, Alwash, Mays, Ferzoco, Alessandra, Vacaresse, Nathalie, Julius, Michael, Gorczysnki, Reginald M., Gariépy, Jean
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2017
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5621893/
https://ncbi.nlm.nih.gov/pubmed/28931757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.94308
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