Stereotyped antibody responses target posttranslationally modified gluten in celiac disease

The role of B cells and posttranslational modifications in pathogenesis of organ-specific immune diseases is increasingly envisioned but remains poorly understood, particularly in human disorders. In celiac disease, transglutaminase 2–modified (TG2-modified; deamidated) gluten peptides drive disease...

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Bibliografiska uppgifter
I publikationen:JCI Insight
Huvudupphovsmän: Snir, Omri, Chen, Xi, Gidoni, Moriah, du Pré, M. Fleur, Zhao, Yuguang, Steinsbø, Øyvind, Lundin, Knut E.A., Yaari, Gur, Sollid, Ludvig M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Clinical Investigation 2017
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5621872/
https://ncbi.nlm.nih.gov/pubmed/28878138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.93961
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