Comparative Pharmacokinetic Study for Linezolid and Two Novel Antibacterial Oxazolidinone Derivatives in Rabbits: Can Differences in the Pharmacokinetic Properties Explain the Discrepancies between Their In Vivo and In Vitro Antibacterial Activities?

This is a comparative pharmacokinetics study of linezolid (Lzd), and two novel oxazolidinone antibacterial agents—PH027 and PH051—in rabbits to determine if the discrepancy between the in vitro and in vivo activities of the novel compounds is due to pharmacokinetic factors. The pharmacokinetics afte...

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Vydáno v:Pharmaceutics
Hlavní autoři: Hedaya, Mohsen A., Thomas, Vidhya, Abdel-Hamid, Mohamed E., Kehinde, Elijah O., Phillips, Oludotun A.
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2017
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5620575/
https://ncbi.nlm.nih.gov/pubmed/28880210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics9030034
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