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Structural and Dynamics Perspectives on the Binding of Substrate and Inhibitors in Mycobacterium tuberculosis DHFR

Dihydrofolate reductase (DHFR), an essential enzyme in the folate pathway, is a potential target for new anti-tuberculosis drugs. Fifteen crystal structures of Mycobacterium tuberculosis DHFR complexed with NADPH and various inhibitors are available in the RCSB Protein Data Bank, but none of them is...

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Publicat a:Sci Pharm
Autors principals: Sittikornpaiboon, Pimonluck, Toochinda, Pisanu, Lawtrakul, Luckhana
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2017
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5620518/
https://ncbi.nlm.nih.gov/pubmed/28914808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/scipharm85030031
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