The identification of novel Mycobacterium tuberculosis DHFR inhibitors and the investigation of their binding preferences by using molecular modelling

It is an urgent need to develop new drugs for Mycobacterium tuberculosis (Mtb), and the enzyme, dihydrofolate reductase (DHFR) is a recognised drug target. The crystal structures of methotrexate binding to mt- and h-DHFR separately indicate that the glycerol (GOL) binding site is likely to be critic...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Hong, Wei, Wang, Yu, Chang, Zhe, Yang, Yanhui, Pu, Jing, Sun, Tao, Kaur, Sargit, Sacchettini, James C., Jung, Hunmin, Lin Wong, Wee, Fah Yap, Lee, Fong Ngeow, Yun, Paterson, Ian C., Wang, Hao
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4607890/
https://ncbi.nlm.nih.gov/pubmed/26471125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep15328
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