The identification of novel Mycobacterium tuberculosis DHFR inhibitors and the investigation of their binding preferences by using molecular modelling

It is an urgent need to develop new drugs for Mycobacterium tuberculosis (Mtb), and the enzyme, dihydrofolate reductase (DHFR) is a recognised drug target. The crystal structures of methotrexate binding to mt- and h-DHFR separately indicate that the glycerol (GOL) binding site is likely to be critic...

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發表在:Sci Rep
Main Authors: Hong, Wei, Wang, Yu, Chang, Zhe, Yang, Yanhui, Pu, Jing, Sun, Tao, Kaur, Sargit, Sacchettini, James C., Jung, Hunmin, Lin Wong, Wee, Fah Yap, Lee, Fong Ngeow, Yun, Paterson, Ian C., Wang, Hao
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 2015
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4607890/
https://ncbi.nlm.nih.gov/pubmed/26471125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep15328
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