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Theoretical Investigation of the Enantioselective Complexations between pfDHFR and Cycloguanil Derivatives
Point mutations in Plasmodium falciparum dihydrofolate reductase (pfDHFR), especially the double mutant variant (A16V + S108T), led to ineffective inhibiting by cycloguanil (Cyc). Cycloguanil derivatives showed good inhibiting properties against wild-type and mutant pfDHFR with an inhibition constan...
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| Publicado no: | Sci Pharm |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5748534/ https://ncbi.nlm.nih.gov/pubmed/29160825 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/scipharm85040037 |
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