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Structure-activity relationship and comparative docking studies for cycloguanil analogs as PfDHFR-TS inhibitors
Drug resistance acquired by Plasmodium falciparum (Pf) is a major problem in the treatment and control of malaria. One of the major examples of drug resistance is that caused by mutations in the active site of dihydrofolate reductase (DHFR) of Pf (PfDHFR-TS). A double mutation, A16V+S108T, is specif...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2771436/ https://ncbi.nlm.nih.gov/pubmed/19588935 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ci9000663 |
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