Detection of ESR1 mutations in circulating cell-free DNA from patients with metastatic breast cancer treated with palbociclib and letrozole

ESR1 mutations are frequently acquired in hormone-resistant metastatic breast cancer (MBC). CDK4/6 inhibition along with endocrine therapy is a promising strategy in hormone receptor-positive MBC. However, the incidence and impact of ESR1 mutations on clinical outcome in patients treated with CDK4/6...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Gyanchandani, Rekha, Kota, Karthik J., Jonnalagadda, Amruth R., Minteer, Tanya, Knapick, Beth A., Oesterreich, Steffi, Brufsky, Adam M., Lee, Adrian V., Puhalla, Shannon L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2016
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5620144/
https://ncbi.nlm.nih.gov/pubmed/28978004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.11383
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