FSensitive detection of mono- and polyclonal ESR1 mutations in primary tumors, metastatic lesions and cell free DNA of breast cancer patients

PURPOSE: Given the clinical relevance of ESR1 mutations as potential drivers of resistance to endocrine therapy, this study used sensitive detection methods to determine the frequency of ESR1 mutations in primary and metastatic breast cancer, and in cell free DNA (cfDNA). PATIENTS AND METHODS: Six E...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Wang, Peilu, Bahreini, Amir, Gyanchandani, Rekha, Lucas, Peter C., Hartmaier, Ryan J., Watters, Rebecca J., Jonnalagadda, Amruth R., Trejo Bittar, Humberto E., Berg, Aaron, Hamilton, Ronald L., Kurland, Brenda F., Weiss, Kurt R., Mathew, Aju, Leone, Jose Pablo, Davidson, Nancy E, Nikiforova, Marina N., Brufsky, Adam M., Ambros, Tadeu F., Stern, Andrew M., Puhalla, Shannon L., Lee, Adrian V., Oesterreich, Steffi
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4775406/
https://ncbi.nlm.nih.gov/pubmed/26500237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-1534
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