FSensitive detection of mono- and polyclonal ESR1 mutations in primary tumors, metastatic lesions and cell free DNA of breast cancer patients

PURPOSE: Given the clinical relevance of ESR1 mutations as potential drivers of resistance to endocrine therapy, this study used sensitive detection methods to determine the frequency of ESR1 mutations in primary and metastatic breast cancer, and in cell free DNA (cfDNA). PATIENTS AND METHODS: Six E...

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Publicado en:Clin Cancer Res
Autores principales: Wang, Peilu, Bahreini, Amir, Gyanchandani, Rekha, Lucas, Peter C., Hartmaier, Ryan J., Watters, Rebecca J., Jonnalagadda, Amruth R., Trejo Bittar, Humberto E., Berg, Aaron, Hamilton, Ronald L., Kurland, Brenda F., Weiss, Kurt R., Mathew, Aju, Leone, Jose Pablo, Davidson, Nancy E, Nikiforova, Marina N., Brufsky, Adam M., Ambros, Tadeu F., Stern, Andrew M., Puhalla, Shannon L., Lee, Adrian V., Oesterreich, Steffi
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4775406/
https://ncbi.nlm.nih.gov/pubmed/26500237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-15-1534
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