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Regulating miRNA-21 Biogenesis By Bi-functional Small Molecules
We report a new strategy to regulate microRNAs (miRNAs) biogenesis by using bi-functional small molecules that consist of a pre-miRNA binding unit connected by a linker to a Dicer inhibiting unit. In this effort, fluorescence polarization-based screening was used to identify neomycin as a pre-miR-21...
Shranjeno v:
| izdano v: | J Am Chem Soc |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2017
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5620130/ https://ncbi.nlm.nih.gov/pubmed/28287718 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b00610 |
| Oznake: |
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