Small RNA zippers lock miRNA molecules and block miRNA function in mammalian cells

MicroRNAs (miRNAs) loss-of-function phenotypes are mainly induced by chemically modified antisense oligonucleotides. Here we develop an alternative inhibitor for miRNAs, termed ‘small RNA zipper'. It is designed to connect miRNA molecules end to end, forming a DNA–RNA duplex through a complemen...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Meng, Lingyu, Liu, Cuicui, Lü, Jinhui, Zhao, Qian, Deng, Shengqiong, Wang, Guangxue, Qiao, Jing, Zhang, Chuyi, Zhen, Lixiao, Lu, Ying, Li, Wenshu, Zhang, Yuzhen, Pestell, Richard G., Fan, Huiming, Chen, Yi-Han, Liu, Zhongmin, Yu, Zuoren
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5216115/
https://ncbi.nlm.nih.gov/pubmed/28045030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13964
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