Small RNA zippers lock miRNA molecules and block miRNA function in mammalian cells

MicroRNAs (miRNAs) loss-of-function phenotypes are mainly induced by chemically modified antisense oligonucleotides. Here we develop an alternative inhibitor for miRNAs, termed ‘small RNA zipper'. It is designed to connect miRNA molecules end to end, forming a DNA–RNA duplex through a complemen...

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Bibliografski detalji
Izdano u:Nat Commun
Glavni autori: Meng, Lingyu, Liu, Cuicui, Lü, Jinhui, Zhao, Qian, Deng, Shengqiong, Wang, Guangxue, Qiao, Jing, Zhang, Chuyi, Zhen, Lixiao, Lu, Ying, Li, Wenshu, Zhang, Yuzhen, Pestell, Richard G., Fan, Huiming, Chen, Yi-Han, Liu, Zhongmin, Yu, Zuoren
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2017
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5216115/
https://ncbi.nlm.nih.gov/pubmed/28045030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13964
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