Small RNA zippers lock miRNA molecules and block miRNA function in mammalian cells

MicroRNAs (miRNAs) loss-of-function phenotypes are mainly induced by chemically modified antisense oligonucleotides. Here we develop an alternative inhibitor for miRNAs, termed ‘small RNA zipper'. It is designed to connect miRNA molecules end to end, forming a DNA–RNA duplex through a complemen...

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Publicado en:Nat Commun
Main Authors: Meng, Lingyu, Liu, Cuicui, Lü, Jinhui, Zhao, Qian, Deng, Shengqiong, Wang, Guangxue, Qiao, Jing, Zhang, Chuyi, Zhen, Lixiao, Lu, Ying, Li, Wenshu, Zhang, Yuzhen, Pestell, Richard G., Fan, Huiming, Chen, Yi-Han, Liu, Zhongmin, Yu, Zuoren
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5216115/
https://ncbi.nlm.nih.gov/pubmed/28045030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13964
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