IRS1 DNA promoter methylation and expression in human adipose tissue are related to fat distribution and metabolic traits

The SNP variant rs2943650 near IRS1 gene locus was previously associated with decreased body fat and IRS1 gene expression as well as an adverse metabolic profile in humans. Here, we hypothesize that these effects may be mediated by an interplay with epigenetic alterations. We measured IRS1 promoter...

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書誌詳細
出版年:Sci Rep
主要な著者: Rohde, Kerstin, Klös, Matthias, Hopp, Lydia, Liu, Xuanshi, Keller, Maria, Stumvoll, Michael, Dietrich, Arne, Schön, Michael R., Gärtner, Daniel, Lohmann, Tobias, Dreßler, Miriam, Kovacs, Peter, Binder, Hans, Blüher, Matthias, Böttcher, Yvonne
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group UK 2017
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5620072/
https://ncbi.nlm.nih.gov/pubmed/28959056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-12393-5
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