IRS1 DNA promoter methylation and expression in human adipose tissue are related to fat distribution and metabolic traits

The SNP variant rs2943650 near IRS1 gene locus was previously associated with decreased body fat and IRS1 gene expression as well as an adverse metabolic profile in humans. Here, we hypothesize that these effects may be mediated by an interplay with epigenetic alterations. We measured IRS1 promoter...

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Pubblicato in:Sci Rep
Autori principali: Rohde, Kerstin, Klös, Matthias, Hopp, Lydia, Liu, Xuanshi, Keller, Maria, Stumvoll, Michael, Dietrich, Arne, Schön, Michael R., Gärtner, Daniel, Lohmann, Tobias, Dreßler, Miriam, Kovacs, Peter, Binder, Hans, Blüher, Matthias, Böttcher, Yvonne
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5620072/
https://ncbi.nlm.nih.gov/pubmed/28959056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-12393-5
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