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Arsenite Binds to the Zinc Finger Motif of TIP60 Histone Acetyltransferase and Induces Its Degradation via the 26S Proteasome

Arsenic is a ubiquitous environmental contaminant with widespread public health concern. Epidemiological studies have revealed that chronic human exposure to arsenic in drinking water is associated with the prevalence of skin, lung, and bladder cancers. Aberrant histone modifications (e.g., methylat...

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Bibliographic Details
Published in:Chem Res Toxicol
Main Authors: Tam, Lok Ming, Jiang, Ji, Wang, Pengcheng, Li, Lin, Miao, Weili, Dong, Xuejiao, Wang, Yinsheng
Format: Artigo
Language:Inglês
Published: 2017
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5620024/
https://ncbi.nlm.nih.gov/pubmed/28837777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrestox.7b00146
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