The Sorting Nexin 3 Retromer Pathway Regulates the Cell Surface Localization and Activity of a Wnt-Activated Polycystin Channel Complex

Autosomal dominant polycystic kidney disease (ADPKD) is caused by inactivating mutations in PKD1 (85%) or PKD2 (15%). The ADPKD proteins encoded by these genes, polycystin-1 (PC1) and polycystin-2 (PC2), form a plasma membrane receptor–ion channel complex. However, the mechanisms controlling the sub...

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Detalhes bibliográficos
Publicado no:J Am Soc Nephrol
Main Authors: Feng, Shuang, Streets, Andrew J., Nesin, Vasyl, Tran, Uyen, Nie, Hongguang, Onopiuk, Marta, Wessely, Oliver, Tsiokas, Leonidas, Ong, Albert C.M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2017
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5619965/
https://ncbi.nlm.nih.gov/pubmed/28620080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2016121349
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