The Polycystin complex mediates WNT/Ca(2+) signaling

WNT ligands induce Ca(2+) signaling on target cells. PKD1 (Polycystin 1) is considered an orphan, atypical G protein coupled receptor complexed with TRPP2 (Polycystin 2 or PKD2), a Ca(2+)-permeable ion channel. Inactivating mutations in their genes cause autosomal dominant polycystic kidney disease...

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Udgivet i:Nat Cell Biol
Main Authors: Kim, Seokho, Nie, Hongguang, Nesin, Vasyl, Tran, Uyen, Outeda, Patricia, Bai, Chang-Xi, Keeling, Jacob, Maskey, Dipak, Watnick, Terry, Wessely, Oliver, Tsiokas, Leonidas
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4925210/
https://ncbi.nlm.nih.gov/pubmed/27214281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3363
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