Hepatocyte Nuclear Factor–1β Regulates Urinary Concentration and Response to Hypertonicity

The transcription factor hepatocyte nuclear factor–1β (HNF-1β) is essential for normal kidney development and function. Inactivation of HNF-1β in mouse kidney tubules leads to early-onset cyst formation and postnatal lethality. Here, we used Pkhd1/Cre mice to delete HNF-1β specifically in renal coll...

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Bibliographic Details
Published in:J Am Soc Nephrol
Main Authors: Aboudehen, Karam, Noureddine, Lama, Cobo-Stark, Patricia, Avdulov, Svetlana, Farahani, Shayan, Gearhart, Micah D., Bichet, Daniel G., Pontoglio, Marco, Patel, Vishal, Igarashi, Peter
Format: Artigo
Language:Inglês
Published: American Society of Nephrology 2017
Subjects:
Basic Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5619957/
https://ncbi.nlm.nih.gov/pubmed/28507058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2016101095
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