Hsp90α Mediates BMI1 Expression in Breast Cancer Stem/Progenitor Cells through Facilitating Nuclear Translocation of c-Myc and EZH2

Heat shock protein 90 (Hsp90) is a molecular chaperone that facilitates the correct folding and functionality of its client protein. Numerous Hsp90-client proteins are involved in cancer development. Thus, Hsp90 inhibitors have potential applications as anti-cancer drugs. We previously discovered th...

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Publicado no:Int J Mol Sci
Main Authors: Lee, Yueh-Chun, Chang, Wen-Wei, Chen, Yi-Ying, Tsai, Yu-Hung, Chou, Ying-Hsiang, Tseng, Hsien-Chun, Chen, Hsin-Lin, Wu, Chun-Chieh, Chang-Chien, Ju, Lee, Hsueh-Te, Yang, Huei-Fan, Wang, Bing-Yen
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5618635/
https://ncbi.nlm.nih.gov/pubmed/28914785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms18091986
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